Hendra and Nipah viruses: different and dangerous

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The natural history of Hendra and Nipah viruses.

Pteropid bats (flying foxes), species of which are the probable natural host of both Hendra and Nipah viruses, occur in overlapping populations from India to Australia. Ecological changes associated with land use and with animal husbandry practices appear most likely to be associated with the emergence of these two agents.

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Hendra and Nipah Virus Diseases

Hendra virus (HeV) and Nipah virus (NiV) emerged in the last decade of the twentieth century as the causes of outbreaks of respiratory and neurological disease that infected a number of animal species. In 1994, HeV caused severe respiratory disease and the death of 13 horses and a horse trainer at a stable in Brisbane, Australia. Between September 1998 and April 1999, after spreading unrecognis...

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Hendra and Nipah Virus Diseases

Hendra virus (HeV) and Nipah virus (NiV) emerged in the last decade of the twentieth century as the causes of outbreaks of respiratory and neurological disease that infected a number of animal species. In 1994, HeV caused severe respiratory disease and the death of 13 horses and a horse trainer at a stable in Brisbane, Australia. Between September 1998 and April 1999, after spreading unrecognis...

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Microsphere Suspension Array Assays for Detection and Differentiation of Hendra and Nipah Viruses

Microsphere suspension array systems enable the simultaneous fluorescent identification of multiple separate nucleotide targets in a single reaction. We have utilized commercially available oligo-tagged microspheres (Luminex MagPlex-TAG) to construct and evaluate multiplexed assays for the detection and differentiation of Hendra virus (HeV) and Nipah virus (NiV). Both these agents are bat-borne...

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Potent neutralization of Hendra and Nipah viruses by human monoclonal antibodies.

Hendra virus (HeV) and Nipah virus (NiV) are closely related emerging viruses comprising the Henipavirus genus of the Paramyxovirinae. Each has a broad species tropism and can cause disease with high mortality in both animal and human hosts. These viruses infect cells by a pH-independent membrane fusion event mediated by their attachment (G) and fusion (F) envelope glycoproteins (Envs). Seven F...

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ژورنال

عنوان ژورنال: Nature Reviews Microbiology

سال: 2006

ISSN: 1740-1526,1740-1534

DOI: 10.1038/nrmicro1323